![]() "We think that this upregulation of MICAL-2 is causing them to be metastatic." "One of the things we're finding that we're really excited by is that there are many cancers, especially metastatic cancers that have the poorest prognosis, that also have very high levels of MICAL-2," Dr. MICAL-2, it turned out, triggered the activity of SRF, reprogramming the transcription in the cells to resemble that seen in metastatic cells. Lundquist examined these cells, he found that SRF had become overactive. (Unregulated cell growth is the fundamental cause of cancer.) When Dr. Jaffrey's lab, found that cells expressing MICAL-2 resembled cancer cells in their shape and high growth rate. Mark Lundquist, a postdoctoral associate in Dr. ![]() Samie Jaffrey, a professor of pharmacology, discovered that an enzyme known as MICAL-2 is necessary for SRF to function in cells. Investigators in the laboratory of senior author Dr. The protein plays a critical role in the life cycle of cells, regulating their growth and controlling their ability to migrate through tissue, a critical step in the process of metastasis. SRF is a transcription factor, meaning that it binds to specific DNA sequences and controls the expression of messenger RNA in a process known as transcription. 16 online edition of Cell, centers on a protein known as serum response factor (SRF). This image shows how MICAL-2 reorganizes actin in the nucleus, which leads to the activation of the SRF transcription factor. Since we have data from the previous census in 2000, we can also compare the values to see how the popularity of Mical has changed in the 10 years between the two census surveys.The SRF pathway is known to be important for the invasion of cancer cells into normal tissue - the process of cancer spread and metastasis. ![]() Note: Any fields showing (S) means the data was suppressed for privacy so that the data does not in any way identify any specific individuals. 3.50%, or 12 total occurrences, were "Hispanic Origin".(S), or less than 100 total occurrences, were "Non-Hispanic of Two or More Races".0.00%, or 0 total occurrences, were "Non-Hispanic American Indian and Alaskan Native".1.46%, or 5 total occurrences, were "Non-Hispanic Asian and Pacific Islander Only".(S), or less than 100 total occurrences, were "Non-Hispanic Black Only".93.00%, or 319 total occurrences, were "Non-Hispanic White Only".All people were categorized into six mutually exclusive racial and Hispanic origin groups: "White only", "Black only", "American Indian and Alaskan Native only", "Asian and Pacific Islander only", "Two or More Races", and "Hispanic".įor the most recent 2010 census data, the race/ethnic origin breakdown for Mical was: The below race categories are the modified race categories used in the Census Bureau's population estimates program. We also have some data on the ancestry of people with the surname Mical. ![]() With a 14-day free trial, it's very easy to get started and discover your past! Get Started → Race and Ethnic Origin of People with the Last Name Mical ![]() With over 30 billion (seriously!) records in their database, you can research your family name and discover amazing details you may never have known about your ancestors. Find out where your family name is from, what your ancestors did for a living, and who they were, using records. ![]()
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